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No one knows what exactly causes fibromyalgia. Some possible triggers can include: Using two separate drugs to shed weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you should err assisting caution and let the FDA do its job and demand some study be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their own medications. Researchers discovered that participants using this drug for any year, dropped a few pounds within four weeks and have kept the body weight off through the 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them far better and safer. Combo-pilling will be the newest fad or also the newest into the future under scrutiny and so it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular could be the fact that at the time of right now there are not any long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug also can raise blood pressure levels and pulse rate, and really should not be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise hypertension and heartbeat and must not used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.